Frizzled-2 is a protein in humans that is encoded by FZD2 gene. Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
The following FZD2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
FZD2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008522 | FZD2 Antibody | Human,Mouse,Rat | WB, IF, ELISA |
CSB-PA596830 | FZD2 Antibody | Human,Mouse,Rat | ELISA,IHC |
FZD2 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-CF884854CH | Recombinant Chicken Frizzled-2 (FZD2) | in vitro E.coli expression system |
CSB-YP884854CH1 CSB-EP884854CH1 CSB-BP884854CH1 CSB-MP884854CH1 CSB-EP884854CH1-B |
Recombinant Chicken Frizzled-2 (FZD2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FZD2 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-CF886106XBE | Recombinant Xenopus laevis Frizzled-2 (fzd2) | in vitro E.coli expression system |
CSB-YP886106XBE1 CSB-EP886106XBE1 CSB-BP886106XBE1 CSB-MP886106XBE1 CSB-EP886106XBE1-B |
Recombinant Xenopus laevis Frizzled-2 (fzd2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FZD2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF622766HU | Recombinant Human Frizzled-2 (FZD2) | in vitro E.coli expression system |
CSB-YP622766HU1 CSB-EP622766HU1 CSB-BP622766HU1 CSB-MP622766HU1 CSB-EP622766HU1-B |
Recombinant Human Frizzled-2 (FZD2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
FZD2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF881309MO | Recombinant Mouse Frizzled-2 (Fzd2) | in vitro E.coli expression system |
CSB-YP881309MO1 CSB-EP881309MO1 CSB-BP881309MO1 CSB-MP881309MO1 CSB-EP881309MO1-B |
Recombinant Mouse Frizzled-2 (Fzd2), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |