GALT

The protein encoded by GALT is galactose-1-phosphate uridylyltransferase (EC 2.7.7.12), commonly known as GALT enzyme. It catalyzes the conversion of galactose-1-phosphate and UDP-glucose to UDP-galactose and glucose-1-phosphate, a key step in galactose metabolism that links galactose utilization to glycolysis for energy homeostasis.
Mutations in GALT cause classic galactosemia, an autosomal recessive disorder leading to galactose accumulation, liver damage, cataracts, and neurodevelopmental defects. Current management relies on galactose-restricted diets; no curative drugs exist yet. Preclinical research explores enzyme replacement therapies and CRISPR-Cas9 gene editing to restore GALT activity, targeting potential curative interventions.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

GALT Antibody (CSB-PA009226LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA009226LA01HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA009226LA01HU at dilution of 1:100

Western Blot
Positive WB detected in: Rat liver tissue, Mouse kidney tissue
All lanes: GALT antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 44, 32 kDa
Observed band size: 44 kDa

Immunofluorescent analysis of Hela cells using CSB-PA009226LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Immunoprecipitating GALT in HepG2 whole cell lysate
Lane 1: Rabbit control IgG instead of CSB-PA009226LA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000)
Lane 2: CSB-PA009226LA01HU (8µg) + HepG2 whole cell lysate (500µg)
Lane 3: HepG2 whole cell lysate (10µg)

The following GALT reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

GALT Antibodies

GALT Proteins

GALT ELISA Kits

GALT Antibodies

GALT Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA009226GA01HU	GALT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA009226LD01HU	GALT Antibody, Biotin conjugated	Human	ELISA
CSB-PA009226LB01HU	GALT Antibody, HRP conjugated	Human	ELISA
CSB-PA009226LA01HU	GALT Antibody	Human, Mouse, Rat	ELISA, WB, IHC, IF, IP
CSB-PA063192	GALT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA902164	GALT Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-RA993143A0HU	GALT Recombinant Monoclonal Antibody	Human	ELISA, FC

GALT Proteins

GALT Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP009226HU CSB-MP009226HU CSB-EP009226HU-B	Recombinant Human Galactose-1-phosphate uridylyltransferase (GALT)	Yeast Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP009226HU	Recombinant Human Galactose-1-phosphate uridylyltransferase (GALT)	E.coli
CSB-EP009226HUc7	Recombinant Human Galactose-1-phosphate uridylyltransferase (GALT)	E.coli
CSB-BP009226HU	Recombinant Human Galactose-1-phosphate uridylyltransferase (GALT)	Homo sapiens (Human)
CSB-BP009226HUa0	Recombinant Human Galactose-1-phosphate uridylyltransferase (GALT)	Homo sapiens (Human)

GALT ELISA Kit

GALT ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL009226HU	Human Galactose-1-phosphate uridylyltransferase(GALT) ELISA kit	serum, plasma, tissue homogenates	2.74 pg/ml

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GALT

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