GCA

The gene "GCA" encodes the Gastric Carboxypeptidase A protein. Also known as CPA3, this enzyme belongs to the carboxypeptidase family. It is mainly secreted by mast cells and participates in the digestion of proteins by cleaving C - terminal aromatic or branched - chain amino acids. It is involved in the renin - angiotensin signaling pathway, regulating blood pressure and fluid balance.
Abnormal expression of GCA is associated with various diseases, such as inflammatory bowel disease and some types of cancers. In drug development, targeting GCA is being explored as a potential therapeutic approach. Some small - molecule inhibitors are under pre - clinical research to modulate its activity for treating related diseases.