GNRH1 encodes the gonadotropin-releasing hormone 1, also known as luteinizing hormone-releasing hormone (LHRH). This neuropeptide plays a crucial role in the reproductive system. It acts on the anterior pituitary gland, binding to specific receptors to stimulate the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This process is mediated by the Gq protein-coupled receptor signaling pathway.
Mutations or dysregulation of GNRH1 are associated with various reproductive disorders, such as hypogonadotropic hypogonadism. In drug development, synthetic analogs of GNRH1 are widely used in the treatment of hormone-dependent cancers, endometriosis, and infertility, showing great potential in clinical applications.
Validated Data
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA238659(GNRH1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA238659(GNRH1 Antibody) at dilution 1/70, on the right is treated with fusion protein. (Original magnification: ×200)
Human gonadotropin-releasing hormone,GnRH ELISA Kit (CSB-E06880h)
Validated Data
Code: CSB-E06880h
Size: 96T,5×96T,10×96T
Sensitivity: 0.625 pg/ml
Detection Range: 2.5 pg/ml-100 pg/ml.
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following GNRH1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
GNRH1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA008890 | GNRH1 Antibody | Human | IHC, ELISA |
CSB-PA238659 | GNRH1 Antibody | Human | ELISA,IHC |
CSB-PA199057 | GNRH1 Antibody | Human | ELISA,IHC |
GNRH1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP009635HU CSB-EP009635HU CSB-BP009635HU CSB-MP009635HU CSB-EP009635HU-B |
Recombinant Human Progonadoliberin-1 (GNRH1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
GNRH1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E06880h | Human gonadotropin-releasing hormone,GnRH ELISA Kit | serum, plasma, tissue homogenates | 0.625 pg/ml |