GYS1

GYS1, known as muscle glycogen synthase, has its activity intricately regulated by multiple factors, with insulin signaling promoting its phosphorylation and enhancing enzyme activity, thus boosting glycogen synthesis. Additionally, GYS1 is modulated by signaling molecules like AMPK, allowing rapid adjustments to glycogen synthesis rates in response to fluctuating energy demands. This enzyme is crucial for maintaining muscle tissue's energy reserves, supporting motor function, and regulating blood glucose levels. Impairments in GYS1 can lead to abnormal glycogen accumulation, impacting muscle function and potentially contributing to metabolic diseases like type 2 diabetes. Understanding GYS1's mechanism and role in disease is vital for developing novel therapeutic approaches.