H2AC18

H2AC18 encodes Histone H2A type 1-C/E/F/G/I, a core nucleosomal component. Common aliases include HIST1H2AC and H2A.1. It forms octameric complexes with H2B, H3, and H4 to stabilize chromatin structure, controlling DNA accessibility for transcriptional machinery. Post-translational modifications like acetylation or phosphorylation of H2AC18 adjust chromatin dynamics, regulating gene expression.
This protein participates in epigenetic pathways linked to DNA damage repair and cell cycle progression. Dysregulated H2AC18 expression or modification is associated with cancers (e.g., colorectal, breast), where abnormal chromatin remodeling drives tumorigenesis. While direct-targeted drugs are scarce, histone deacetylase (HDAC) inhibitors—modulating H2AC18 acetylation—are in clinical use or development for cancer therapy, aiming to restore normal epigenetic regulation.