HAGH

The gene HAGH encodes a protein known as glutathione hydrolase, also referred to as GLO2. This enzyme plays a crucial role in the hydrolysis of S-lactoyl-glutathione, converting it into reduced glutathione and D-lactate. It is involved in the glyoxylate cycle and is thought to contribute to the regulation of oxidative stress and inflammation. HAGH is associated with various diseases, including age-related macular degeneration and cardiovascular diseases. In terms of drug development, research is ongoing to explore the potential of targeting HAGH for therapeutic interventions, particularly in conditions where oxidative stress and inflammation are significant contributors.