IARS1

IARS1 encodes isoleucyl-tRNA synthetase 1, an enzyme also known as IleRS. This protein is crucial for protein synthesis, catalyzing the attachment of isoleucine to its cognate tRNA. It participates in the translational machinery, ensuring accurate incorporation of isoleucine into nascent polypeptides.
Mutations in IARS1 have been linked to various neurodegenerative diseases, such as Charcot - Marie - Tooth disease. Regarding drug development, research is ongoing to target IARS1 for potential treatments. Inhibitors may offer new therapeutic strategies for diseases associated with abnormal IARS1 function, although much work remains in pre - clinical and clinical studies.