IFIH1

The IFIH1 gene encodes the interferon-induced helicase C domain-containing protein 1, also known as melanoma differentiation-associated protein 5 (MDA5). This protein is a key component of the innate immune system. It senses viral double - stranded RNA, activating signaling cascades that lead to the production of type I interferons. The RIG - I - like receptor signaling pathway is closely related to its function.
Mutations in IFIH1 are associated with various autoimmune diseases, such as Aicardi - Goutières syndrome and Singleton - Merten syndrome. In drug development, targeting the function of the protein encoded by IFIH1 holds promise for treating these immune - related disorders, but research is still in the early stages.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP880143HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) IFIH1.

IFIH1 Recombinant Monoclonal Antibody (CSB-RA963423A0HU)

Validated Data

Western Blot
Positive WB detected in: THP-1 whole cell lysate, Mouse lung tissue
All lanes: MDA5 antibody at 1:2000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 117, 26 kDa
Observed band size: 117 kDa

The following IFIH1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

IFIH1 Antibodies

IFIH1 Proteins

IFIH1 Antibodies

IFIH1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA011017GA01HU	IFIH1 Antibody	Human	ELISA,WB
CSB-PA255539	IFIH1 Antibody	Human,Mouse	ELISA,WB
CSB-PA880143ESR2HU	IFIH1 Antibody	Human	ELISA, IHC
CSB-PA003209	IFIH1 Antibody	Human,Mouse	WB, IHC, ELISA
CSB-PA880143LA01HU	IFIH1 Antibody	Human	ELISA, IHC, IF
CSB-PA880143LB01HU	IFIH1 Antibody, HRP conjugated	Human	ELISA
CSB-PA880143LC01HU	IFIH1 Antibody, FITC conjugated	Human
CSB-PA880143LD01HU	IFIH1 Antibody, Biotin conjugated	Human	ELISA
CSB-RA963423A0HU	IFIH1 Recombinant Monoclonal Antibody	Human, Mouse	ELISA, WB

IFIH1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA819199ZA01MO	Ifih1 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

IFIH1 Proteins

IFIH1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP819199MO CSB-BP819199MO CSB-MP819199MO CSB-EP819199MO-B	Recombinant Mouse Interferon-induced helicase C domain-containing protein 1 (Ifih1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP819199MO	Recombinant Mouse Interferon-induced helicase C domain-containing protein 1 (Ifih1), partial	E.coli

IFIH1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP880143HU CSB-BP880143HU CSB-MP880143HU CSB-EP880143HU-B	Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP880143HU	Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial	E.coli
CSB-EP880143HUa2	Recombinant Human Interferon-induced helicase C domain-containing protein 1 (IFIH1), partial	E.coli

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IFIH1

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