IL1R1

IL1R1, interleukin-1 receptor 1, alias CD121a, IL1R, IL1RA, IL1RT1. it is a receptor protein on cell membranes and belongs to a key component of the interleukin 1 (IL-1) signaling pathway. IL1R1 is derived from a variety of cell types, including specific endothelial cells, ventricular cells, astrocytes, and neurons.
IL1R1 regulates the transcription of multiple pro-inflammatory cytokines and mediates immune and inflammatory responses by binding to IL-1α, IL-1β, IL-1Ra, and IL-38 and activating signaling pathways including NF-κB and MAPK.
IL1R1 plays an important role in immune regulation and inflammatory processes, and it plays a key regulatory role in many inflammatory and immune diseases, such as rheumatoid arthritis, inflammatory bowel disease, and rheumatoid arthritis. It is a potential target for the treatment of these diseases.