IL1R1 (Interleukin-1 Receptor Type 1) is a member of the interleukin-1 (IL-1) family. It is a single transmembrane protein consisting of extracellular, transmembrane, and intracellular domains. The extracellular region contains multiple structural domains, including three immunoglobulin-like domains, which are responsible for binding to cytokines. When the body is exposed to infection, injury, or other inflammatory stimuli, cells produce IL-1, which then binds to IL1R1 on the cell surface, forming the IL-1/IL1R1 complex. This complex activates intracellular signaling pathways such as NF-κB and MAPK, triggering inflammatory responses and immune reactions. IL1R1 plays a significant role in immune regulation and inflammatory processes. It exerts critical regulatory functions in various inflammatory and immune-related diseases, including rheumatoid arthritis, inflammatory bowel disease, and systemic juvenile idiopathic arthritis. As a result, IL1R1 has emerged as a potential therapeutic target for treating these conditions.
● IL1R1 Recombinant Monoclonal Antibody CSB-RA011621MA1HU
Validated Data
Overlay Peak curve showing NIH/3T3 cells stained with CSB-RA011621MA1HU (red line) at 1:50. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1µg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1µg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
● Recombinant Human Interleukin-1 receptor type 1(IL1R1) CSB-CF011621HU
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
The following IL1R1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
IL1R1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA011621ESR1HU | IL1R1 Antibody |
Human, Mouse | ELISA, WB, IHC |
CSB-PA011621ESR2HU | IL1R1 Antibody |
Human | ELISA, IHC |
CSB-PA005251 | IL1R1 Antibody |
Human | WB, ELISA |
CSB-PA009540 | Phospho-IL1R1 (Y496) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA727952 | IL1R1 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA072110 | IL1R1 Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA011621EA01HU | IL1R1 Antibody |
Human | ELISA, WB, IF |
CSB-PA011621EB01HU | IL1R1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA011621EC01HU | IL1R1 Antibody, FITC conjugated |
Human | |
CSB-PA011621ED01HU | IL1R1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA011621MA1HU | IL1R1 Recombinant Monoclonal Antibody |
Human, Mouse | ELISA, FC |
IL1R1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP011621HU CSB-EP011621HU CSB-BP011621HU CSB-MP011621HU CSB-EP011621HU-B |
Recombinant Human Interleukin-1 receptor type 1 (IL1R1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1) |
in vitro E.coli expression system |
CSB-MP011621HU | Recombinant Human Interleukin-1 receptor type 1 (IL1R1)-VLPs |
Mammalian cell |
IL1R1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-CF011621MO | Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1) |
in vitro E.coli expression system |
CSB-YP011621MO1 CSB-EP011621MO1 CSB-BP011621MO1 CSB-MP011621MO1 CSB-EP011621MO1-B |
Recombinant Mouse Interleukin-1 receptor type 1 (Il1r1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
IL1R1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E04611h | Human soluble interleukin-1 receptor Ⅰ,IL-1sRⅠ ELISA kit |
serum, plasma,tissue homogenates | 0.039 ng/ml |