KDELR2

KDEL endoplasmic reticulum protein retention receptor 2 (KDELR2), also known as ERD2-like protein 2, is a Golgi-localized transmembrane receptor. It mediates retrograde transport of ER-resident proteins bearing the KDEL (Lys-Asp-Glu-Leu) motif from the Golgi back to the ER, ensuring endoplasmic reticulum homeostasis and proper protein folding.
Aberrant KDELR2 expression correlates with breast cancer (overexpression drives tumor aggressiveness) and neurodegenerative disorders linked to ER stress. While no targeted drugs are in clinical trials, preclinical studies explore small-molecule modulators to inhibit its function, aiming to disrupt cancer cell survival or alleviate ER stress-related pathologies.

Popular Product:

KDELR2 Antibody (CSB-PA003095)

Validated Data

Western Blot analysis of COLO205 cells using KDEL Receptor 2 Polyclonal Antibody

The following KDELR2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

KDELR2 Antibodies

KDELR2 Proteins

KDELR2 Antibodies

KDELR2 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA003095	KDELR2 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA

KDELR2 Proteins

KDELR2 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF012130HU	Recombinant Human ER lumen protein retaining receptor 2 (KDELR2)	in vitro E.coli expression system
CSB-YP012130HU1 CSB-EP012130HU1 CSB-BP012130HU1 CSB-MP012130HU1 CSB-EP012130HU1-B	Recombinant Human ER lumen protein retaining receptor 2 (KDELR2), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

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