LATS1

Serine/threonine-protein kinase LATS1 is a protein in humans that is encoded by LATS1 gene. Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

LATS1 Antibodies

LATS1 Antibodies for Homo sapiens (Human)

LATS1 Antibodies for Mus musculus (Mouse)

LATS1 Proteins

LATS1 Proteins for Homo sapiens (Human)

LATS1 Proteins for Mus musculus (Mouse)

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