LGMN

LGMN encodes the protein Legumain, also commonly known as asparaginyl endopeptidase. This protein is a cysteine protease that plays crucial roles in both normal physiological processes and pathological conditions. It functions by cleaving peptide bonds at the carboxyl side of asparagine residues. Legumain is involved in the endocytic pathway and is often associated with antigen processing.
In terms of diseases, elevated levels of Legumain are linked to various cancers, facilitating tumor growth and metastasis. It's also implicated in neurodegenerative diseases like Alzheimer's. Currently, several inhibitors targeting Legumain are in pre - clinical development, aiming to provide new therapeutic strategies for related diseases.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

LGMN Antibody (CSB-PA012903LA01HU)

Validated Data

IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

IHC image of CSB-PA012903LA01HU diluted at 1:600 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human Legumain(LGMN) ELISA kit (CSB-EL012903HU)

Validated Data

Code: CSB-EL012903HU

Size: 96T,5×96T,10×96T

Sensitivity: 15.6 pg/mL

Detection Range: 62.5 pg/mL-4000 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following LGMN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

LGMN Antibodies

LGMN Proteins

LGMN ELISA Kits

LGMN Antibodies

LGMN Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA012903LA01HU	LGMN Antibody	Human	ELISA, IHC
CSB-PA012903LB01HU	LGMN Antibody, HRP conjugated	Human	ELISA
CSB-PA012903LC01HU	LGMN Antibody, FITC conjugated	Human
CSB-PA012903LD01HU	LGMN Antibody, Biotin conjugated	Human	ELISA

LGMN Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA012903ZA01MO	Lgmn Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

LGMN Antibodies for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Species Reactivity	Application
CSB-PA012903ZA01MOV	LGMN Antibody	Macaca fascicularis	ELISA, WB (ensure identification of antigen)

LGMN Proteins

LGMN Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP012903MO	Recombinant Mouse Legumain (Lgmn)	Yeast
CSB-EP012903MO	Recombinant Mouse Legumain (Lgmn)	E.coli
CSB-BP012903MO CSB-MP012903MO CSB-EP012903MO-B	Recombinant Mouse Legumain (Lgmn)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LGMN Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)

Code	Product Name	Source
CSB-YP012903PYX CSB-EP012903PYX CSB-BP012903PYX CSB-MP012903PYX CSB-EP012903PYX-B	Recombinant Pongo abelii Legumain (LGMN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LGMN Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP012903BO CSB-EP012903BO CSB-BP012903BO CSB-MP012903BO CSB-EP012903BO-B	Recombinant Bovine Legumain (LGMN)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LGMN Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP012903HU	Recombinant Human Legumain (LGMN)	Yeast
CSB-EP012903HU	Recombinant Human Legumain (LGMN)	E.coli
CSB-BP012903HU CSB-MP012903HU CSB-EP012903HU-B	Recombinant Human Legumain (LGMN)	Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP012903HU(A4)	Recombinant Human Legumain(LGMN)	Yeast

LGMN Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP012903RA CSB-EP012903RA CSB-BP012903RA CSB-MP012903RA CSB-EP012903RA-B	Recombinant Rat Legumain (Lgmn)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

LGMN Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-YP012903MOV CSB-BP012903MOV CSB-MP012903MOV CSB-EP012903MOV-B	Recombinant Macaca fascicularis Legumain (LGMN)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP012903MOV	Recombinant Macaca fascicularis Legumain (LGMN)	E.coli
CSB-BP012903MOVb1	Recombinant Macaca fascicularis Legumain (LGMN)	Baculovirus

LGMN ELISA Kit

LGMN ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL012903HU	Human Legumain(LGMN) ELISA kit	serum, plasma, tissue homogenates	15.6 pg/mL

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LGMN

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