Low-density lipoprotein receptor-related protein 6 is a protein in humans that is encoded by LRP6 gene. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
The following LRP6 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
LRP6 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA013102ESR2HU | LRP6 Antibody |
Human | ELISA, IHC |
CSB-PA234397 | LRP6 Antibody |
Human,Mouse | ELISA,IHC |
LRP6 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP013102HU CSB-EP013102HU CSB-BP013102HU CSB-MP013102HU CSB-EP013102HU-B |
Recombinant Human Low-density lipoprotein receptor-related protein 6 (LRP6), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LRP6 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP013102MO CSB-EP013102MO CSB-BP013102MO CSB-MP013102MO CSB-EP013102MO-B |
Recombinant Mouse Low-density lipoprotein receptor-related protein 6 (Lrp6), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
LRP6 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E08952h | Human low-density lipoprotein-receptor-related protein,LRP-6 ELISA Kit |
serum, tissue homogenates, cell lysates | 0.078 ng/mL |