LRRC8A

LRRC8A, a member of the leucine-rich repeat family and aliased as SWELL1, is encoded by the LRRC8A gene. It forms part of a family known for its ability to create heterologous multi-body complexes, known as volume-regulated anion channels (VRAC). LRRC8A's mechanism includes the regulation of cell volume in response to osmotic pressure changes by forming chloride channels, allowing chloride ions to exit the cell. This protein is vital for cell survival under conditions of high osmotic pressure, such as high salt concentrations, by maintaining cell volume and function through rapid responses to osmotic shock. LRRC8A also plays a role in B cell development, and mutations in its gene can lead to gammaglobulinemia, a primary immunodeficiency characterized by an absence of serum antibodies and circulating B cells.

Popular Product:

Recombinant Human Leucine-rich repeat-containing protein 8A (LRRC8A), partial