LTA4H

The gene LTA4H encodes the protein leukotriene A4 hydrolase (LTA4H), also known as leukotriene A-4 hydrolase. LTA4H is a key enzyme in the biosynthesis of leukotriene B4 (LTB4), a pro-inflammatory lipid mediator. It catalyzes the conversion of LTA4 to LTB4, which plays a crucial role in immune responses and inflammation. LTA4H inhibition modulates LT signaling pathways, impacting synaptic organization, structure, and activity. This enzyme is associated with various diseases, including age-related cognitive decline and Alzheimer's disease. Drug development targeting LTA4H has shown promise, with novel inhibitors like LYS006 undergoing clinical trials for the treatment of neutrophil-driven inflammatory diseases.