MAGEC2

MAGEC2, also known as Melanoma-associated Antigen C2, is a protein that plays a significant role in cancer biology. It is a member of the MAGE family, which is characterized by its expression in various cancers, including breast, prostate, and multiple myeloma. MAGEC2 functions by interacting with E3 ubiquitin ligases, influencing protein degradation and regulation within the cell. This protein is associated with tumor growth, survival, and immune evasion mechanisms, particularly through its interaction with the tumor suppressor protein p53 and the STAT3 signaling pathway. Its expression is linked to poor prognosis in breast cancer, and it has been identified as a potential therapeutic target for cancer treatment. Research into MAGEC2 modulators and their potential applications in treating immune-related disorders is ongoing, with promising results in enhancing the efficacy of existing treatments and providing new avenues for tackling resistant tumors.