MAPKAPK3

MAPKAPK3, or mitogen-activated protein kinase-activated protein kinase 3, is a serine/threonine kinase also known as 3pK or MAPKAP kinase-3. It functions downstream of MAPK pathways, particularly p38 and ERK, phosphorylating substrates like HSP27 to regulate cellular processes including stress response, inflammation, and cell proliferation.
Aberrant MAPKAPK3 activity correlates with cancer progression, neurodegenerative disorders, and metabolic diseases. Preclinical studies explore small-molecule inhibitors targeting its kinase domain, with promising results in suppressing tumor growth in xenograft models, though clinical development remains in early stages.

Popular Product:

MAPKAPK3 Antibody (CSB-PA620974ESR1HU)

Validated Data

Western blot
All lanes: MAPKAPK3 antibody at 4.4µg/ml
Lane 1: Hela whole cell lysate
Lane 2: Jurkat whole cell lysate
Lane 3: MCF-7 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA620974ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA620974ESR1HU at dilution of 1:100

The following MAPKAPK3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

MAPKAPK3 Antibodies

MAPKAPK3 Proteins

MAPKAPK3 Antibodies

MAPKAPK3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA247267	MAPKAPK3 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA000766	MAPKAPK3 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA620974ESR1HU	MAPKAPK3 Antibody	Human	ELISA, WB, IHC

MAPKAPK3 Proteins

MAPKAPK3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP620974HU CSB-EP620974HU CSB-BP620974HU CSB-MP620974HU CSB-EP620974HU-B	Recombinant Human MAP kinase-activated protein kinase 3 (MAPKAPK3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAPKAPK3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP659737MO CSB-EP659737MO CSB-BP659737MO CSB-MP659737MO CSB-EP659737MO-B	Recombinant Mouse MAP kinase-activated protein kinase 3 (Mapkapk3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAPKAPK3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP663576BO CSB-EP663576BO CSB-BP663576BO CSB-MP663576BO CSB-EP663576BO-B	Recombinant Bovine MAP kinase-activated protein kinase 3 (MAPKAPK3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

MAPKAPK3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP724116RA CSB-EP724116RA CSB-BP724116RA CSB-MP724116RA CSB-EP724116RA-B	Recombinant Rat MAP kinase-activated protein kinase 3 (Mapkapk3)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

Promotions

Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application