MLH1

DNA mismatch repair protein Mlh1 is a protein in humans that is encoded by MLH1 gene. Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

MLH1 Antibodies

MLH1 Antibodies for Homo sapiens (Human)

Code Product Name Species Reactivity Application
CSB-PA014624GA01HU MLH1 Antibody Human,Mouse,Rat ELISA,WB
CSB-PA003247 MLH1 Antibody Human,Mouse,Rat WB,IF,ELISA
CSB-PA236767 MLH1 Antibody Human,Mouse,Rat ELISA,IHC
CSB-PA091025 MLH1 Antibody Human,Mouse,Rat ELISA,IHC
CSB-PA17009A0Rb MLH1 Antibody Human, Mouse ELISA, WB, IHC, IF
CSB-PA17009B0Rb MLH1 Antibody, HRP conjugated Human ELISA
CSB-PA17009C0Rb MLH1 Antibody, FITC conjugated Human ELISA
CSB-PA17009D0Rb MLH1 Antibody, Biotin conjugated Human ELISA

MLH1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

Code Product Name Species Reactivity Application
CSB-PA819964XA01DOA MLH1 Antibody Arabidopsis thaliana ELISA, WB (ensure identification of antigen)

MLH1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code Product Name Species Reactivity Application
CSB-PA014624XA01SVG MLH1 Antibody Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) ELISA, WB (ensure identification of antigen)

MLH1 Proteins

MLH1 Proteins for Rattus norvegicus (Rat)

Code Product Name Source
CSB-YP014624RA Recombinant Rat DNA mismatch repair protein Mlh1(Mlh1),Yeast Yeast
CSB-EP014624RA Recombinant Rat DNA mismatch repair protein Mlh1(Mlh1),Escherichia Coli E.coli
CSB-BP014624RA Recombinant Rat DNA mismatch repair protein Mlh1(Mlh1),Baculovirus Baculovirus
CSB-MP014624RA Recombinant Rat DNA mismatch repair protein Mlh1(Mlh1),Mammalian cell Mammalian cell

MLH1 Proteins for Homo sapiens (Human)

Code Product Name Source
CSB-YP014624HU Recombinant Human DNA mismatch repair protein Mlh1(MLH1),Yeast Yeast
CSB-EP014624HU Recombinant Human DNA mismatch repair protein Mlh1(MLH1),Escherichia Coli E.coli
CSB-BP014624HU Recombinant Human DNA mismatch repair protein Mlh1(MLH1),Baculovirus Baculovirus
CSB-MP014624HU Recombinant Human DNA mismatch repair protein Mlh1(MLH1),Mammalian cell Mammalian cell

MLH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code Product Name Source
CSB-YP014624SVG Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH1(MLH1) ,partial,Yeast Yeast
CSB-EP014624SVG Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH1(MLH1) ,partial,Escherichia Coli E.coli
CSB-BP014624SVG Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH1(MLH1) ,partial,Baculovirus Baculovirus
CSB-MP014624SVG Recombinant Saccharomyces cerevisiae DNA mismatch repair protein MLH1(MLH1) ,partial,Mammalian cell Mammalian cell

MLH1 Proteins for Dictyostelium discoideum (Slime mold)

Code Product Name Source
CSB-YP700781DKK Recombinant Dictyostelium discoideum DNA mismatch repair protein Mlh1(mlh1) ,partial,Yeast Yeast
CSB-EP700781DKK Recombinant Dictyostelium discoideum DNA mismatch repair protein Mlh1(mlh1) ,partial,Escherichia Coli E.coli
CSB-BP700781DKK Recombinant Dictyostelium discoideum DNA mismatch repair protein Mlh1(mlh1) ,partial,Baculovirus Baculovirus
CSB-MP700781DKK Recombinant Dictyostelium discoideum DNA mismatch repair protein Mlh1(mlh1) ,partial,Mammalian cell Mammalian cell

MLH1 Proteins for Mus musculus (Mouse)

Code Product Name Source
CSB-YP878086MO Recombinant Mouse DNA mismatch repair protein Mlh1(Mlh1),Yeast Yeast
CSB-EP878086MO Recombinant Mouse DNA mismatch repair protein Mlh1(Mlh1),Escherichia Coli E.coli
CSB-BP878086MO Recombinant Mouse DNA mismatch repair protein Mlh1(Mlh1),Baculovirus Baculovirus
CSB-MP878086MO Recombinant Mouse DNA mismatch repair protein Mlh1(Mlh1),Mammalian cell Mammalian cell

MLH1 cDNA

MLH1 cDNA for Mus musculus (Mouse)

Code Product Name Vector Accession NO.
CSB-CL878086MO Mlh1 pUC NM_026810.2

MLH1 cDNA for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

Code Product Name Vector Accession NO.
CSB-CL014624SVG MLH1 pUC NM_001182671.1

MLH1 cDNA for Homo sapiens (Human)

Code Product Name Vector Accession NO.
CSB-CL014624HU1 MLH1 pUC NM_000249.3
CSB-CL014624HU2 MLH1 pUC NM_001167617.1
CSB-CL014624HU3 MLH1 pUC NM_001167618.1
CSB-CL014624HU4 MLH1 pUC NM_001167619.1
CSB-CL014624HU5 MLH1 pUC NM_001258271.1
CSB-CL014624HU6 MLH1 pUC NM_001258273.1
CSB-CL014624HU7 MLH1 pUC NM_001258274.1

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