DNA mismatch repair protein Mlh1 is a protein in humans that is encoded by MLH1 gene. Heterodimerizes with PMS2 to form MutL alpha, a component of the post-replicative DNA mismatch repair system (MMR). DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected.

MLH1 Antibodies

MLH1 Antibodies for Homo sapiens (Human)

MLH1 Antibodies for Human

MLH1 Antibodies for Arabidopsis thaliana (Mouse-ear cress)

MLH1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

MLH1 Proteins

MLH1 Proteins for Rattus norvegicus (Rat)

MLH1 Proteins for Homo sapiens (Human)

MLH1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

MLH1 Proteins for Dictyostelium discoideum (Slime mold)

MLH1 Proteins for Mus musculus (Mouse)


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