MYD88, myeloid differentiation factor 88, is a transcription factor expressed in hematopoietic stem cells and lymphoid tissues that is widely involved in immune signaling.MYD88 is derived from the body's own genetic code, and it serves as a key articulatory protein for intracellular signaling, mediating the signaling of various Toll-like receptors (TLRs), interleukin 1 receptors (IL-1R), and interleukin-18 receptors (IL-18R). 18 receptor (IL-18R) signaling, and plays a prominent role in intrinsic immunity.The mechanism of action of MYD88 involves its interaction with various receptors, recognizing signals upon receptor activation through its TIR structural domain (Toll-Interleukin 1 Receptor Domain), which in turn recruits and activates downstream signaling molecules, such as IRAK (Interleukin-1 Receptor-Associated Kinase). This leads to the activation of transcription factors such as nuclear factor-κB (NF-κB) and MAPK (mitogen-activated protein kinase), which regulate the expression of inflammatory factors.The signaling pathways of MYD88 include, but are not limited to, the NF-κB pathway, the JAK-STAT3 (tyrosine kinase-signal transducer and activator of transcription 3) signaling pathway, which play a key role in cell proliferation and differentiation, as well as in inflammatory responses.
The biological significance of MYD88 is mainly reflected in its regulation of the intrinsic immune response. It is not only involved in pathogen recognition and initiation of inflammatory responses, but also closely related to the pathogenesis of tumors, infectious diseases, autoimmune diseases, etc. MYD88-dependent signaling pathways are considered as potential targets for the treatment of these diseases. In particular, certain mutations in the MYD88 gene, such as L265P, can lead to increased production of inflammatory factors, which is particularly important in diseases such as lymphoplasmacytic lymphoma. Therefore, the study of MYD88 not only helps us to understand the complexity of the immune response, but also offers the possibility of developing new therapeutic strategies.
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) (CSB-EP859945HU)
Validated Data
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP859945HU could indicate that this peptide derived from E.coli-expressed Homo sapiens (Human) MYD88.
MYD88 Antibody (CSB-PA859945LA01HU)
Validated Data
Immunofluorescent analysis of HepG2 cells using CSB-PA859945LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Human myeloid differentiation factor 88, MyD88 ELISA Kit (CSB-E11747h)
Validated Data
Code: CSB-E11747h
Size: 96T,5×96T,10×96T
Sensitivity: 0.078 ng/mL
Detection Range: 0.312ng/mL-20ng/mL
These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
The following MYD88 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MYD88 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA003338 | MYD88 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA995911 | MYD88 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA859945LA01HU | MYD88 Antibody | Human | ELISA, IF |
CSB-PA859945LB01HU | MYD88 Antibody, HRP conjugated | Human | ELISA |
CSB-PA859945LC01HU | MYD88 Antibody, FITC conjugated | Human | |
CSB-PA859945LD01HU | MYD88 Antibody, Biotin conjugated | Human | ELISA |
MYD88 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA730396XA01DIL | myd88 Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
MYD88 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015282MO CSB-EP015282MO CSB-BP015282MO CSB-MP015282MO CSB-EP015282MO-B |
Recombinant Mouse Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP015282PI CSB-EP015282PI CSB-BP015282PI CSB-MP015282PI CSB-EP015282PI-B |
Recombinant Pig Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015282CH CSB-EP015282CH CSB-BP015282CH CSB-MP015282CH CSB-EP015282CH-B |
Recombinant Chicken Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Macaca mulatta (Rhesus macaque)
Code | Product Name | Source |
---|---|---|
CSB-YP015282MOW CSB-EP015282MOW CSB-BP015282MOW CSB-MP015282MOW CSB-EP015282MOW-B |
Recombinant Macaca mulatta (Rhesus macaque) Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Ovis aries (Sheep)
Code | Product Name | Source |
---|---|---|
CSB-YP015282SH CSB-EP015282SH CSB-BP015282SH CSB-MP015282SH CSB-EP015282SH-B |
Recombinant Sheep Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Code | Product Name | Source |
---|---|---|
CSB-YP015282TKY CSB-EP015282TKY CSB-BP015282TKY CSB-MP015282TKY CSB-EP015282TKY-B |
Recombinant Takifugu rubripes Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Salmo salar (Atlantic salmon)
Code | Product Name | Source |
---|---|---|
CSB-YP015282SWI CSB-EP015282SWI CSB-BP015282SWI CSB-MP015282SWI CSB-EP015282SWI-B |
Recombinant Salmo salar Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
Code | Product Name | Source |
---|---|---|
CSB-YP015282MOV CSB-EP015282MOV CSB-BP015282MOV CSB-MP015282MOV CSB-EP015282MOV-B |
Recombinant Macaca fascicularis Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Gorilla gorilla gorilla (Western lowland gorilla)
Code | Product Name | Source |
---|---|---|
CSB-YP015282GGZ CSB-EP015282GGZ CSB-BP015282GGZ CSB-MP015282GGZ CSB-EP015282GGZ-B |
Recombinant Gorilla gorilla gorilla Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pan troglodytes (Chimpanzee)
Code | Product Name | Source |
---|---|---|
CSB-YP015282EQV CSB-EP015282EQV CSB-BP015282EQV CSB-MP015282EQV CSB-EP015282EQV-B |
Recombinant Pan troglodytes Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pan paniscus (Pygmy chimpanzee) (Bonobo)
Code | Product Name | Source |
---|---|---|
CSB-YP015282EQU CSB-EP015282EQU CSB-BP015282EQU CSB-MP015282EQU CSB-EP015282EQU-B |
Recombinant Pan paniscus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Pongo pygmaeus (Bornean orangutan)
Code | Product Name | Source |
---|---|---|
CSB-YP015282EXP CSB-EP015282EXP CSB-BP015282EXP CSB-MP015282EXP CSB-EP015282EXP-B |
Recombinant Pongo pygmaeus Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys)
Code | Product Name | Source |
---|---|---|
CSB-YP015282DRI CSB-EP015282DRI CSB-BP015282DRI CSB-MP015282DRI CSB-EP015282DRI-B |
Recombinant Cercocebus atys Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Code | Product Name | Source |
---|---|---|
CSB-YP635725XBF CSB-EP635725XBF CSB-BP635725XBF CSB-MP635725XBF CSB-EP635725XBF-B |
Recombinant Xenopus tropicalis Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP685436BO CSB-EP685436BO CSB-BP685436BO CSB-MP685436BO CSB-EP685436BO-B |
Recombinant Bovine Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Code | Product Name | Source |
---|---|---|
CSB-YP708955OEI CSB-EP708955OEI CSB-BP708955OEI CSB-MP708955OEI CSB-EP708955OEI-B |
Recombinant Oncorhynchus mykiss Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP730396DIL CSB-EP730396DIL CSB-BP730396DIL CSB-MP730396DIL CSB-EP730396DIL-B |
Recombinant Danio rerio Myeloid differentiation primary response protein MyD88 (myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP744333RA CSB-EP744333RA CSB-BP744333RA CSB-MP744333RA CSB-EP744333RA-B |
Recombinant Rat Myeloid differentiation primary response protein MyD88 (Myd88) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP859945HU CSB-BP859945HU CSB-MP859945HU CSB-EP859945HU-B |
Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MYD88 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-EP859945HU | Recombinant Human Myeloid differentiation primary response protein MyD88 (MYD88) | E.coli |
MYD88 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E11747h | Human myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 0.078 ng/mL |
MYD88 ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E12109m | Mouse myeloid differentiation factor 88, MyD88 ELISA Kit | serum, plasma, tissue homogenates, cell lysates | 11.7 pg/mL |