NCOA3

NCOA3, also known as nuclear receptor coactivator 3, is a protein that plays a crucial role in the coactivation of various nuclear receptors. It enhances the transcriptional activity of these receptors by recruiting coactivator proteins and histone acetyltransferases. NCOA3 is involved in several signaling pathways, including those related to steroid, retinoid, thyroid hormone, and vitamin D3 receptors. Its dysregulation is associated with various diseases, such as breast cancer, where it promotes tumor growth and resistance to hormonal therapy. Recent research has identified NCOA3 inhibitors as potential therapeutic agents for cancer and metabolic disorders, offering new avenues for drug development.