NCR3

The NCR3 gene encodes the Natural Cytotoxicity Triggering Receptor 3 protein, also commonly known as NKp30. This protein is a key component of the natural killer (NK) cell's recognition system. It binds to specific ligands on target cells, activating NK cells to release cytokines and perform cytotoxic functions. It is involved in the innate immune response signaling pathway.
Alterations in NCR3 and NKp30 have been associated with various diseases, including certain viral infections and some cancers. In drug development, there is ongoing research to target NCR3 and NKp30 to enhance NK cell - mediated immunity, with the goal of developing new immunotherapies for disease treatment.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Activity
Measured by its binding ability in a functional ELISA. Immobilized Human NCR3 at 5 μg/ml can bind human NCR3LG1(CSB-MP737873HU-B). The EC₅₀ is 111.3-303.1 ng/mL.

NCR3 Antibody (CSB-PA015551LA01HU)

Validated Data

Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA015551LA01HU at dilution of 1:100

Immunofluorescence staining of HepG2 cells with CSB-PA015551LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

The following NCR3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NCR3 Antibodies

NCR3 Proteins

NCR3 Antibodies

NCR3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA006291	NCR3 Antibody	Human,Rat	WB, ELISA
CSB-PA008587	NCR3 Antibody	Human,Rat	WB, ELISA
CSB-PA031920	NCR3 Antibody	Human	ELISA,IHC
CSB-PA899163	NCR3 Antibody	Human	ELISA,IHC
CSB-PA015551LA01HU	NCR3 Antibody	Human	ELISA, IHC, IF
CSB-PA015551LB01HU	NCR3 Antibody, HRP conjugated	Human	ELISA
CSB-PA015551LD01HU	NCR3 Antibody, Biotin conjugated	Human	ELISA

NCR3 Proteins

NCR3 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP015551RA CSB-EP015551RA CSB-BP015551RA CSB-MP015551RA CSB-EP015551RA-B	Recombinant Rat Natural cytotoxicity triggering receptor 3 (Ncr3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NCR3 Proteins for Macaca mulatta (Rhesus macaque)

Code	Product Name	Source
CSB-YP015551MOW CSB-EP015551MOW CSB-BP015551MOW CSB-MP015551MOW CSB-EP015551MOW-B	Recombinant Macaca mulatta Natural cytotoxicity triggering receptor 3 (NCR3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NCR3 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Code	Product Name	Source
CSB-CF015551MOV	Recombinant Macaca fascicularis Natural cytotoxicity triggering receptor 3 (NCR3)	in vitro E.coli expression system
CSB-YP015551MOV1 CSB-EP015551MOV1 CSB-BP015551MOV1 CSB-EP015551MOV1-B	Recombinant Macaca fascicularis Natural cytotoxicity triggering receptor 3 (NCR3), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli

NCR3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF015551HU	Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3)	in vitro E.coli expression system
CSB-YP015551HU1 CSB-EP015551HU1 CSB-BP015551HU1 CSB-EP015551HU1-B	Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial	Yeast E.coli Baculovirus In Vivo Biotinylation in E.coli
CSB-MP015551HU1	Recombinant Human Natural cytotoxicity triggering receptor 3 (NCR3), partial (Active)	Mammalian cell

NCR3 Proteins for Pan troglodytes (Chimpanzee)

Code	Product Name	Source
CSB-CF015551EQV	Recombinant Pan troglodytes Natural cytotoxicity triggering receptor 3 (NCR3)	in vitro E.coli expression system
CSB-YP015551EQV1 CSB-EP015551EQV1 CSB-BP015551EQV1 CSB-MP015551EQV1 CSB-EP015551EQV1-B	Recombinant Pan troglodytes Natural cytotoxicity triggering receptor 3 (NCR3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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NCR3

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