Endonuclease 8-like 1 is a protein in humans that is encoded by NEIL1 gene. Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U.
The following NEIL1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NEIL1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA846619LA01HU | NEIL1 Antibody |
Human | ELISA, IHC |
CSB-PA015693GA01HU | NEIL1 Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA003395 | NEIL1 Antibody |
Human | WB, ELISA |
NEIL1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP809118MO CSB-EP809118MO CSB-BP809118MO CSB-MP809118MO CSB-EP809118MO-B |
Recombinant Mouse Endonuclease 8-like 1 (Neil1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NEIL1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP846619HU CSB-BP846619HU CSB-MP846619HU CSB-EP846619HU-B |
Recombinant Human Endonuclease 8-like 1 (NEIL1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP846619HU | Recombinant Human Endonuclease 8-like 1 (NEIL1) |
E.coli |