NFATC1, identified as nuclear factor-activated T cell 1, is a transcription factor pivotal in immune response gene regulation, particularly within T and B cells. Its mechanism involves calcineurin activation, which prompts NFATC1's translocation from the cytoplasm to the nucleus to modulate target gene expression. This factor plays a central role in immune response modulation, influencing cell proliferation, differentiation, and migration, thereby preserving immune system equilibrium. Disruptions in NFATC1 expression are linked to a spectrum of diseases, such as autoimmune conditions, cardiovascular issues, and cancer, underscoring its broad implications for health and disease.
NFATC1 Antibody (CSB-PA17827A0Rb)
Validated Data
IHC image of CSB-PA17827A0Rb diluted at 1:1200 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescent analysis of HepG2 cells using CSB-PA17827A0Rb at dilution of 1: 100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
The following NFATC1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NFATC1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA005617 | NFATC1 Antibody | Human,Mouse | WB, ELISA |
CSB-PA020078 | Phospho-NFATC1 (S294) Antibody | Human,Mouse | IHC, ELISA |
CSB-PA239200 | NFATC1 Antibody | Human,Mouse | ELISA,IHC |
CSB-PA17827A0Rb | NFATC1 Antibody | Human | ELISA, IHC, IF |
CSB-PA17827C0Rb | NFATC1 Antibody, FITC conjugated | Human | |
CSB-PA17827D0Rb | NFATC1 Antibody, Biotin conjugated | Human | ELISA |
NFATC1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP015745BO CSB-EP015745BO CSB-BP015745BO CSB-MP015745BO CSB-EP015745BO-B |
Recombinant Bovine Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFATC1 Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP015745PI CSB-EP015745PI CSB-BP015745PI CSB-MP015745PI CSB-EP015745PI-B |
Recombinant Pig Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFATC1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015745MO CSB-EP015745MO CSB-BP015745MO CSB-MP015745MO CSB-EP015745MO-B |
Recombinant Mouse Nuclear factor of activated T-cells, cytoplasmic 1 (Nfatc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NFATC1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015745HU CSB-EP015745HU CSB-BP015745HU CSB-MP015745HU CSB-EP015745HU-B |
Recombinant Human Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |