NPM1

NPM1, or nuclear phosphoprotein 1, is a multifunctional chaperone located in the cell nucleolus and shuttling between the nucleus and cytoplasm, involved in ribosome synthesis, centrosome replication, and DNA repair. It interacts with proteins like P53 and ARF to regulate apoptosis. NPM1's mechanism includes various protein interactions, affecting cell cycle regulation, proliferation, differentiation, and apoptosis. It is highly expressed in various malignant tumor cells, such as acute myeloid leukemia (AML), with its mutant form being relevant to disease pathogenesis and serving as an indicator for monitoring minimal residual disease (MRD). NPM1's abnormal expression or dysfunction is closely associated with tumor development and is a key target in malignant tumor research and treatment.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

NPM1 Antibody (CSB-PA003492)

Validated Data

Western Blot analysis of COS7 cells using Nucleophosmin Polyclonal Antibody

Western Blot analysis of 293 AD293 cells using Nucleophosmin Polyclonal Antibody

Human Nucleophosmin(NPM1) ELISA kit (CSB-EL015996HU)

Validated Data

Code: CSB-EL015996HU

Size: 96T,5×96T,10×96T

Sensitivity: 5.8 pg/mL

Detection Range: 23.5 pg/mL-1500 pg/mL

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following NPM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

NPM1 Antibodies

NPM1 Proteins

NPM1 ELISA Kits

NPM1 Antibodies

NPM1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA015996GA01HU	NPM1 Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA582765	Phospho-NPM1 (Thr199) Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA003471	NPM1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA003492	NPM1 Antibody	Human,Mouse,Rat,Monkey	WB, IHC, ELISA
CSB-PA020150	Phospho-NPM1 (T234) Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA020151	Phospho-NPM1 (T199) Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA
CSB-PA020152	NPM1 Antibody	Human,Mouse,Rat	WB, IHC, IF, ELISA

NPM1 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA737048ZA01MO	Npm1 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

NPM1 Proteins

NPM1 Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP015996RA CSB-EP015996RA CSB-BP015996RA CSB-MP015996RA CSB-EP015996RA-B	Recombinant Rat Nucleophosmin (Npm1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPM1 Proteins for Gallus gallus (Chicken)

Code	Product Name	Source
CSB-YP015996CH CSB-EP015996CH CSB-BP015996CH CSB-MP015996CH CSB-EP015996CH-B	Recombinant Chicken Nucleophosmin (NPM1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPM1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP015996HU CSB-BP015996HU CSB-MP015996HU CSB-EP015996HU-B	Recombinant Human Nucleophosmin (NPM1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP015996HU	Recombinant Human Nucleophosmin (NPM1)	E.coli

NPM1 Proteins for Xenopus laevis (African clawed frog)

Code	Product Name	Source
CSB-YP015996XBE CSB-EP015996XBE CSB-BP015996XBE CSB-MP015996XBE CSB-EP015996XBE-B	Recombinant Xenopus laevis Nucleophosmin (npm1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPM1 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP663615BO CSB-EP663615BO CSB-BP663615BO CSB-MP663615BO CSB-EP663615BO-B	Recombinant Bovine Nucleophosmin (NPM1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

NPM1 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP737048MO CSB-BP737048MO CSB-MP737048MO CSB-EP737048MO-B	Recombinant Mouse Nucleophosmin (Npm1)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP737048MO	Recombinant Mouse Nucleophosmin (Npm1)	E.coli

NPM1 ELISA Kit

NPM1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-EL015996HU	Human Nucleophosmin(NPM1) ELISA kit	serum, plasma, tissue homogenates, cell lysates	5.8 pg/mL

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Popular Pathways

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NPM1

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