Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
The following NPM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NPM1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015996GA01HU | NPM1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA582765 | Phospho-NPM1 (Thr199) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA003471 | NPM1 Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA003492 | NPM1 Antibody |
Human,Mouse,Rat,Monkey | WB, IHC, ELISA |
CSB-PA020150 | Phospho-NPM1 (T234) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020151 | Phospho-NPM1 (T199) Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
CSB-PA020152 | NPM1 Antibody |
Human,Mouse,Rat | WB, IHC, IF, ELISA |
NPM1 Antibodies for Mus musculus (Mouse)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA737048ZA01MO | Npm1 Antibody |
Mus musculus | ELISA, WB (ensure identification of antigen) |
NPM1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP015996RA CSB-EP015996RA CSB-BP015996RA CSB-MP015996RA CSB-EP015996RA-B |
Recombinant Rat Nucleophosmin (Npm1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015996CH CSB-EP015996CH CSB-BP015996CH CSB-MP015996CH CSB-EP015996CH-B |
Recombinant Chicken Nucleophosmin (NPM1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015996HU CSB-BP015996HU CSB-MP015996HU CSB-EP015996HU-B |
Recombinant Human Nucleophosmin (NPM1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP015996XBE CSB-EP015996XBE CSB-BP015996XBE CSB-MP015996XBE CSB-EP015996XBE-B |
Recombinant Xenopus laevis Nucleophosmin (npm1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP663615BO CSB-EP663615BO CSB-BP663615BO CSB-MP663615BO CSB-EP663615BO-B |
Recombinant Bovine Nucleophosmin (NPM1) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NPM1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP737048MO CSB-BP737048MO CSB-MP737048MO CSB-EP737048MO-B |
Recombinant Mouse Nucleophosmin (Npm1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP737048MO | Recombinant Mouse Nucleophosmin (Npm1) |
E.coli |
NPM1 ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL015996HU | Human Nucleophosmin(NPM1) ELISA kit |
serum, plasma, tissue homogenates, cell lysates | 5.8 pg/mL |