NPNT

The protein corresponding to the gene NPNT is nephronectin. It has no widely - known common aliases. Nephronectin is an extracellular matrix protein that binds to integrin receptors on cell surfaces. This interaction promotes cell adhesion, migration, and differentiation, which is crucial during kidney development and tissue repair.
In terms of signaling pathways, it is involved in the integrin - mediated signaling cascade. Dysregulation of NPNT has been linked to kidney diseases such as nephrotic syndrome. Currently, research is in progress to develop drugs that target the NPNT - integrin axis to treat related kidney disorders.