NTRK1, Neurotrophic Factor Receptor Tyrosine Kinase 1, aliases include TRKA, Neurotrophic Tyrosine Kinase Receptor Type 1, and so on. It is a membrane-bound receptor, encoded by the NTRK1 gene, which mainly functions in the nervous system and is involved in the regulation of cell proliferation, differentiation, and survival.The mechanism of action of NTRK1 is to activate its intrinsic tyrosine kinase activity by binding to neurotrophic factors, thereby triggering intracellular signaling and affecting cell survival and differentiation.The signaling pathways of NTRK1 include MAPK and PI3K/AKT signaling pathways, which are important for tumor cell proliferation and survival.
The biological significance of NTRK1 is mainly reflected in its role in the development and functional maintenance of the nervous system.NTRK1 fusion-positive tumors arise from fusion of the NTRK1/2/3 genes with other genes, which results in abnormalities in the encoded TRK protein. The sustained activation of the mutated TRK or TRK fusion proteins triggers a permanent signaling cascade, and these proteins are a major driver of tumor growth and metastasis in patients with TRK fusion cancers.The NTRK1 gene fusion may be found in tumors originating in different locations in the body, which has made it one of the targets for researchers to develop "open-ended" therapies. This makes it one of the targets for researchers developing "cancer-neutral" therapies.
NTRK1 Recombinant Monoclonal Antibody (CSB-RA202683A0HU)
Validated Data
Western Blot
Positive WB detected in: Rat Brain whole cell lysate, Mouse Brain whole cell lysate
All lanes: TrkA Antibody at 1:1000
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 88, 87, 84, 78 kDa
Observed band size: 145 kDa
The following NTRK1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NTRK1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA198739 | Phospho-NTRK1 (Ser791) Antibody | Human | ELISA,WB,IF |
CSB-PA217013 | NTRK1 (Ab-791) Antibody | Human | ELISA,IF |
CSB-PA095633 | Phospho-NTRK1 (Tyr680/681) Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA078103 | Phospho-NTRK1 (Tyr791) Antibody | Human | ELISA,IHC |
CSB-PA271642 | Phospho-NTRK1 (Tyr757) Antibody | Human,Mouse | ELISA,IHC |
CSB-PA830815 | Phospho-NTRK1 (Tyr701) Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA020162 | Phospho-NTRK1 (Y680/Y681) Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA020164 | Phospho-NTRK1 (Y701) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020165 | Phospho-NTRK1 (Y791) Antibody | Human | IHC, ELISA |
CSB-PA020166 | Phospho-NTRK1 (Y757) Antibody | Human,Mouse,Rat | IHC, ELISA |
CSB-PA020167 | Phospho-NTRK1 (Y496) Antibody | Human,Mouse,Rat | IF, ELISA |
CSB-PA020168 | NTRK1 Antibody | Human | IHC, IF, ELISA |
CSB-PA020169 | NTRK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020170 | NTRK1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA979780 | NTRK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA140509 | NTRK1 Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA016133LA01HU | NTRK1 Antibody | Human, Mouse, Rat | ELISA, WB, IHC, IF |
CSB-PA016133LB01HU | NTRK1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA016133LC01HU | NTRK1 Antibody, FITC conjugated | Human | |
CSB-PA016133LD01HU | NTRK1 Antibody, Biotin conjugated | Human | ELISA |
CSB-RA202683A0HU | NTRK1 Recombinant Monoclonal Antibody | Human, Mouse, Rat | ELISA, WB |
NTRK1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP667566MO CSB-EP667566MO CSB-BP667566MO CSB-MP667566MO CSB-EP667566MO-B |
Recombinant Mouse High affinity nerve growth factor receptor (Ntrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP835489CH CSB-EP835489CH CSB-BP835489CH CSB-MP835489CH CSB-EP835489CH-B |
Recombinant Chicken High affinity nerve growth factor receptor (NTRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF016133HU | Recombinant Human High affinity nerve growth factor receptor (NTRK1) | in vitro E.coli expression system |
CSB-YP016133HU1 CSB-EP016133HU1 CSB-BP016133HU1 CSB-MP016133HU1 CSB-EP016133HU1-B |
Recombinant Human High affinity nerve growth factor receptor (NTRK1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF016133RA | Recombinant Rat High affinity nerve growth factor receptor (Ntrk1) | in vitro E.coli expression system |
CSB-YP016133RA1 CSB-EP016133RA1 CSB-BP016133RA1 CSB-MP016133RA1 CSB-EP016133RA1-B |
Recombinant Rat High affinity nerve growth factor receptor (Ntrk1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |