High affinity nerve growth factor receptor is a protein in humans that is encoded by NTRK1 gene. Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand.
The following NTRK1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NTRK1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA198739 | Phospho-NTRK1 (Ser791) Antibody |
Human | ELISA,WB,IF |
CSB-PA217013 | NTRK1 (Ab-791) Antibody |
Human | ELISA,IF |
CSB-PA095633 | Phospho-NTRK1 (Tyr680/681) Antibody |
Human,Mouse,Rat | ELISA,WB |
CSB-PA078103 | Phospho-NTRK1 (Tyr791) Antibody |
Human | ELISA,IHC |
CSB-PA271642 | Phospho-NTRK1 (Tyr757) Antibody |
Human,Mouse | ELISA,IHC |
CSB-PA830815 | Phospho-NTRK1 (Tyr701) Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA020162 | Phospho-NTRK1 (Y680/Y681) Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA020164 | Phospho-NTRK1 (Y701) Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020165 | Phospho-NTRK1 (Y791) Antibody |
Human | IHC, ELISA |
CSB-PA020166 | Phospho-NTRK1 (Y757) Antibody |
Human,Mouse,Rat | IHC, ELISA |
CSB-PA020167 | Phospho-NTRK1 (Y496) Antibody |
Human,Mouse,Rat | IF, ELISA |
CSB-PA020168 | NTRK1 Antibody |
Human | IHC, IF, ELISA |
CSB-PA020169 | NTRK1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020170 | NTRK1 Antibody |
Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA979780 | NTRK1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA140509 | NTRK1 Antibody |
Human,Mouse,Rat | ELISA,IHC |
CSB-PA016133LA01HU | NTRK1 Antibody |
Human, Mouse, Rat | ELISA, WB, IHC, IF |
CSB-PA016133LB01HU | NTRK1 Antibody, HRP conjugated |
Human | ELISA |
CSB-PA016133LC01HU | NTRK1 Antibody, FITC conjugated |
Human | |
CSB-PA016133LD01HU | NTRK1 Antibody, Biotin conjugated |
Human | ELISA |
CSB-RA202683A0HU | NTRK1 Recombinant Monoclonal Antibody |
Human, Mouse, Rat | ELISA, WB |
NTRK1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP667566MO CSB-EP667566MO CSB-BP667566MO CSB-MP667566MO CSB-EP667566MO-B |
Recombinant Mouse High affinity nerve growth factor receptor(Ntrk1),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP835489CH CSB-EP835489CH CSB-BP835489CH CSB-MP835489CH CSB-EP835489CH-B |
Recombinant Chicken High affinity nerve growth factor receptor(NTRK1),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-CF016133HU | Recombinant Human High affinity nerve growth factor receptor(NTRK1) |
in vitro E.coli expression system |
CSB-YP016133HU1 CSB-EP016133HU1 CSB-BP016133HU1 CSB-MP016133HU1 CSB-EP016133HU1-B |
Recombinant Human High affinity nerve growth factor receptor(NTRK1),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NTRK1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-CF016133RA | Recombinant Rat High affinity nerve growth factor receptor(Ntrk1) |
in vitro E.coli expression system |
CSB-YP016133RA1 CSB-EP016133RA1 CSB-BP016133RA1 CSB-MP016133RA1 CSB-EP016133RA1-B |
Recombinant Rat High affinity nerve growth factor receptor(Ntrk1),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
The NTRK1 gene encodes a protein that is essential for the development and survival of neurons, especially those that transmit information about sensations such as pain, temperature, and sensory neurons [1]. The NTRK1 protein is found on the surface of cells, particularly sensory neurons. It acts as a kinase, which is an enzyme that changes the activity of other proteins by adding a cluster of oxygen and a phosphate group at specific positions, a process known as phosphorylation. The NTRK1 protein is activated when another protein called nerve growth factor beta (NGFβ) binds to it and signals the NTRK1 protein to phosphorylate itself (autophosphorylation). The activated NTRK1 protein and then phosphorylates other proteins, thus finishing the delivery of signals for cell growth and survival. Gene fusions involving NTRK1 have been shown to be oncogenic, leading to the constitutive TrkA activation [2]. Mutations in NTRK1 gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behaviors, intellectual disability and/or cognitive impairment and certain cancers.
[1] Martin-Zanca D, Hughes SH, et al. A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences [J]. Nature. 1986, 319 (6056): 743–8.
[2] Vaishnavi, Aria; Capelletti, Marzia; et al. Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer [J]. Nature Medicine. 2013, 19 (11): 1469–1472.