NTRK1

NTRK1, Neurotrophic Factor Receptor Tyrosine Kinase 1, aliases include TRKA, Neurotrophic Tyrosine Kinase Receptor Type 1, and so on. It is a membrane-bound receptor, encoded by the NTRK1 gene, which mainly functions in the nervous system and is involved in the regulation of cell proliferation, differentiation, and survival.The mechanism of action of NTRK1 is to activate its intrinsic tyrosine kinase activity by binding to neurotrophic factors, thereby triggering intracellular signaling and affecting cell survival and differentiation.The signaling pathways of NTRK1 include MAPK and PI3K/AKT signaling pathways, which are important for tumor cell proliferation and survival.

The biological significance of NTRK1 is mainly reflected in its role in the development and functional maintenance of the nervous system.NTRK1 fusion-positive tumors arise from fusion of the NTRK1/2/3 genes with other genes, which results in abnormalities in the encoded TRK protein. The sustained activation of the mutated TRK or TRK fusion proteins triggers a permanent signaling cascade, and these proteins are a major driver of tumor growth and metastasis in patients with TRK fusion cancers.The NTRK1 gene fusion may be found in tumors originating in different locations in the body, which has made it one of the targets for researchers to develop "open-ended" therapies. This makes it one of the targets for researchers developing "cancer-neutral" therapies.