OPA1

OPA1 is a protein that primarily functions on the inner mitochondrial membrane. It regulates the fusion of mitochondria, thus maintaining their shape and function. OPA1 also plays a role in assembling respiratory chain super complexes and reshaping mitochondrial cristae. OPA1 is crucial for cellular energy metabolism, cell death, proliferation, and gene expression regulation. Thus, OPA1, a crucial protein for mitochondrial function and cellular processes, is linked to various diseases, notably optic atrophy (ADOA) and neurological disorders.