PLBD2

PLBD2 encodes the Phospholipase B Domain Containing 2 protein, often abbreviated as PLB2 in research contexts. This protein belongs to the phospholipase B family, catalyzing the hydrolysis of both acyl ester and phosphodiester bonds in phospholipids—key for lipid metabolism and membrane homeostasis. It regulates lipid signaling pathways and membrane turnover by breaking down cellular phospholipids.
Dysregulation of PLBD2 is associated with metabolic disorders like non-alcoholic fatty liver disease (NAFLD) and obesity, where impaired lipid metabolism disrupts cellular function. Preclinical studies explore targeting its enzymatic activity to restore lipid balance, though no PLBD2-specific drugs have entered clinical trials to date.