PREP

PREP, also known as prolyl endopeptidase, is a serine protease widely distributed in the brain, liver and immune cells. It specifically cleaves peptide bonds at proline residues, regulating the metabolism of neuropeptides and hormones to maintain neural and cellular homeostasis.
Dysregulated PREP activity is associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s, as well as certain cancers and inflammatory disorders. Multiple small-molecule PREP inhibitors are under preclinical and early clinical development, showing potential for treating neurodegenerative conditions.

Popular Product:

PITRM1 Antibody (CSB-PA692283ESR2HU)

Validated Data

Western blot
All lanes: PITRM1 antibody at 2.42μg/ml
Lane 1: Mouse placenta tissue
Lane 2: A549 whole cell lysate
Lane 3: Rat gonad tissue
Lane 4: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 118, 107 kDa
Observed band size: 118, 50 kDa

Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA692283ESR2HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA692283ESR2HU at dilution of 1:100

The following PREP reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

PREP Antibodies

PREP Proteins

PREP Antibodies

PREP Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA018041GA01HU	PITRM1 Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA018664GA01HU	PREP Antibody	Human,Mouse,Rat	ELISA,WB,IHC
CSB-PA692283ESR1HU	PITRM1 Antibody	Human, Mouse	ELISA, WB, IHC
CSB-PA692283ESR2HU	PITRM1 Antibody	Human, Mouse, Rat	ELISA, WB, IHC
CSB-PA018664LA01HU	PREP Antibody	Human	ELISA, WB, IHC, IF
CSB-PA018664LB01HU	PREP Antibody, HRP conjugated	Human	ELISA
CSB-PA018664LC01HU	PREP Antibody, FITC conjugated	Human
CSB-PA018664LD01HU	PREP Antibody, Biotin conjugated	Human	ELISA

PREP Proteins

PREP Proteins for Sus scrofa (Pig)

Code	Product Name	Source
CSB-YP018664PI CSB-EP018664PI CSB-BP018664PI CSB-MP018664PI CSB-EP018664PI-B	Recombinant Pig Prolyl endopeptidase (PREP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PREP Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP018664HU(A4) CSB-BP018664HU(A4) CSB-MP018664HU(A4) CSB-EP018664HU(A4)-B	Recombinant Human Prolyl endopeptidase (PREP)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-YP692283HU CSB-EP692283HU CSB-BP692283HU CSB-MP692283HU CSB-EP692283HU-B	Recombinant Human Presequence protease, mitochondrial (PITRM1), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP018664HU	Recombinant Human Prolyl endopeptidase (PREP), partial	E.coli

PREP Proteins for Rattus norvegicus (Rat)

Code	Product Name	Source
CSB-YP018664RA CSB-EP018664RA CSB-BP018664RA CSB-MP018664RA CSB-EP018664RA-B	Recombinant Rat Prolyl endopeptidase (Prep)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PREP Proteins for Dictyostelium discoideum (Slime mold)

Code	Product Name	Source
CSB-YP018664DKK CSB-EP018664DKK CSB-BP018664DKK CSB-MP018664DKK CSB-EP018664DKK-B	Recombinant Dictyostelium discoideum Prolyl endopeptidase (prep), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PREP Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-YP018664MO CSB-BP018664MO CSB-MP018664MO CSB-EP018664MO-B	Recombinant Mouse Prolyl endopeptidase (Prep)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

PREP Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-YP018664BO CSB-EP018664BO CSB-BP018664BO CSB-MP018664BO CSB-EP018664BO-B	Recombinant Bovine Prolyl endopeptidase (PREP), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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