PTK2B

Protein-tyrosine kinase 2-beta is a protein in humans that is encoded by PTK2B gene. Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress.

PTK2B Antibodies

PTK2B Antibodies for Homo sapiens (Human)

PTK2B Proteins

PTK2B Proteins for Rattus norvegicus (Rat)

PTK2B Proteins for Homo sapiens (Human)

PTK2B Proteins for Mus musculus (Mouse)

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