PTPN2

PTPN2, or non-receptor type protein tyrosine phosphatase 2, alias TCPTP, TCELLPTP, TC-PTP, etc.. It is a protein encoded by the human cell's own gene, belongs to the protein tyrosine phosphatase family members, has a highly conserved catalytic motif, and plays an important role in the regulation of cellular processes such as cell growth, differentiation, mitotic cycle, and anti-tumor transformation.The mechanism of action of PTPN2 mainly involves its dephosphorylation activity, which modulates a variety of signaling pathways, including JAK/STAT, TCR, TCELLPTP, TC-PTP, etc., by removing the phosphorylation group from the protein tyrosine residues.

PTPN2 regulates a variety of signaling pathways, including JAK/STAT, TCR, IFN-γ, etc. These signaling pathways are important for tumor cells. These signaling pathways have key roles in tumor cell proliferation, differentiation, survival and tumor immunity. In tumor immunity, deletion of PTPN2 enhances T cell activity and promotes tumor cell sensitivity to immunotherapy, by enhancing IFNγ-mediated antigen presentation and inhibiting tumor growth.The biological significance of PTPN2 lies in its complex role in tumor development and tumor immunity. On the one hand, deletion of PTPN2 may promote immune escape of tumor cells; on the other hand, its role in T cells may contribute to the enhancement of immune responses to tumors. Thus, PTPN2 is an important target in tumor therapy and immunomodulation studies, and the development of its inhibitors provides new strategies for cancer immunotherapy .

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Recombinant Human Tyrosine-protein phosphatase non-receptor type 2 (PTPN2)