The protein encoded by the PVR gene, also known as poliovirus receptor, is a transmembrane glycoprotein. It is commonly referred to as CD155 and has been implicated in various cellular processes, including cell adhesion, migration, and immune regulation. PVR interacts with immune cell receptors such as DNAM-1, TIGIT, and CD96, influencing immune cell activation or inhibition. This protein is overexpressed in several human malignancies, where it promotes tumor cell invasion, migration, and proliferation. The PVR pathway is involved in tumor immunosuppression and is a target for anti-tumor therapies, including checkpoint inhibitors and adoptive cell therapies. Research into PVR as a therapeutic target has led to the development of novel drugs and immunotherapies.
Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) (CSB-MP019093HU(M))
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
PVR Recombinant Monoclonal Antibody (CSB-RA567944A0HU)
Validated Data
Western Blot
Positive WB detected in: A549 whole cell lysate
All lanes: Poliovirus Receptor antibody at 1:500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 70 kDa
Observed band size: 70 kDa
IHC image of CSB-RA567944A0HU diluted at 1:50 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.42% DAB.
The following PVR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PVR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019093ESR1HU | PVR Antibody | Human, Mouse | ELISA, WB, IHC |
CSB-PA019093ESR2HU | PVR Antibody | Human | ELISA, IHC |
CSB-PA006288 | PVR Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA297000 | PVR Antibody | Human | ELISA,WB,IHC |
CSB-RA567944A0HU | PVR Recombinant Monoclonal Antibody | Human | ELISA, WB, IHC |
PVR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019093HU CSB-BP019093HU CSB-MP019093HU CSB-EP019093HU-B |
Recombinant Human Poliovirus receptor (PVR), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF019093HU(A4) | Recombinant Human Poliovirus receptor (PVR) | in vitro E.coli expression system |
CSB-EP019093HU | Recombinant Human Poliovirus receptor (PVR), partial | E.coli |
CSB-MP019093HU(M) | Recombinant Human Poliovirus receptor (PVR) (I340M), partial (Active) | Mammalian cell |
CSB-MP019093HU(A4) | Recombinant Human Poliovirus receptor (PVR)-VLPs | Mammalian cell |
CSB-MP019093HUc7 | Recombinant Human Poliovirus receptor (PVR), partial | Mammalian cell |
PVR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP341328DSU CSB-EP341328DSU CSB-BP341328DSU CSB-MP341328DSU CSB-EP341328DSU-B |
Recombinant Chlorocebus aethiops Poliovirus receptor homolog (PVR), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PVR ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL019093HU | Human Poliovirus receptor(PVR) ELISA kit | serum, plasma, tissue homogenates | 1.95 ng/mL |