PVR is a gene providing an instruction of making a protein named poliovirus receptor (usually abbreviated as PVR). PVR protein, also known as CD155, is a type I transmembrane glycoprotein belonging to IgSF.
Due to the different splicing modes of PVR at the mRNA level, four isotypes of PVR protein (α, β, γ, and δ) have been found. The first two are membrane-type molecules, and the latter two are soluble-type molecules. The presence of soluble CD155 (sCD155) can be detected in the cerebrospinal fluid and the culture supernatant of some colon cancer cell lines. CD155 is mainly expressed in endothelial cells, central nervous system and some tumor cells. The CD155 is constitutively expressed on the surface of osteoclasts and the corresponding interstitial cell membrane, and is stably expressed in all stages of osteoclast formation. After binding to its receptor CD226, it can transmit inhibitory signals and inhibit osteoclast fusion by inhibiting osteoclast fusion. Involved in the negative regulation of osteoclastogenesis.
Recombinant Human Poliovirus receptor(PVR)(I340M),partial (Active) (CSB-MP019093HU(M))
Validated Data
Greater than 95% as determined by SDS-PAGE.
FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.
The following PVR reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
PVR Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA019093ESR1HU | PVR Antibody |
Human, Mouse | ELISA, WB, IHC |
CSB-PA019093ESR2HU | PVR Antibody |
Human | ELISA, IHC |
CSB-PA006288 | PVR Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA297000 | PVR Antibody |
Human | ELISA,WB,IHC |
PVR Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP019093HU CSB-BP019093HU CSB-MP019093HU CSB-EP019093HU-B |
Recombinant Human Poliovirus receptor(PVR),partial |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-CF019093HU(A4) | Recombinant Human Poliovirus receptor(PVR) |
in vitro E.coli expression system |
CSB-EP019093HU | Recombinant Human Poliovirus receptor(PVR),partial |
E.coli |
CSB-MP019093HU(M) | Recombinant Human Poliovirus receptor(PVR)(I340M),partial (Active) |
Mammalian cell |
CSB-MP019093HU(A4) | Recombinant Human Poliovirus receptor(PVR)-VLPs |
Mammalian cell |
PVR Proteins for Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
Code | Product Name | Source |
---|---|---|
CSB-YP341328DSU CSB-EP341328DSU CSB-BP341328DSU CSB-MP341328DSU CSB-EP341328DSU-B |
Recombinant Chlorocebus aethiops Poliovirus receptor homolog(PVR),partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
PVR ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL019093HU | Human Poliovirus receptor(PVR) ELISA kit |
serum, plasma, tissue homogenates | 1.95 ng/mL |