PVR Research Reagents

PVR is a gene providing an instruction of making a protein named poliovirus receptor (usually abbreviated as PVR). PVR protein, also known as CD155, is a type I transmembrane glycoprotein belonging to IgSF.

Due to the different splicing modes of PVR at the mRNA level, four isotypes of PVR protein (α, β, γ, and δ) have been found. The first two are membrane-type molecules, and the latter two are soluble-type molecules. The presence of soluble CD155 (sCD155) can be detected in the cerebrospinal fluid and the culture supernatant of some colon cancer cell lines. CD155 is mainly expressed in endothelial cells, central nervous system and some tumor cells. The CD155 is constitutively expressed on the surface of osteoclasts and the corresponding interstitial cell membrane, and is stably expressed in all stages of osteoclast formation. After binding to its receptor CD226, it can transmit inhibitory signals and inhibit osteoclast fusion by inhibiting osteoclast fusion. Involved in the negative regulation of osteoclastogenesis.

Popular Product

Recombinant Human Poliovirus receptor(PVR)(I340M),partial (Active) (CSB-MP019093HU(M))

Validated Data

Purity determined by SDS-PAGE

Greater than 95% as determined by SDS-PAGE.

The binding activity of PVR-TIGIT validated by FACS

FACS assay shows that Human PVR can bind to HEK293F cell overexpressing human TIGIT.