RING1

RING1, also known as Really Interesting New Gene 1, is a key component of the Polycomb Repressive Complex 1 (PRC1). It is commonly referred to as RNF71. This protein plays a fundamental role in gene silencing through its E3 ubiquitin - ligase activity, which mediates the monoubiquitination of histone H2A at lysine 119, leading to chromatin compaction.
RING1 is involved in the Wnt and Notch signaling pathways. Aberrant regulation of RING1 has been associated with various cancers, including leukemia and solid tumors. In drug development, targeting the E3 ubiquitin - ligase activity of RING1 is an emerging strategy, with several pre - clinical studies exploring potential small - molecule inhibitors to modulate its function.