RRAGA, Ras-related GTP-binding protein A, alias FIP1, RAGA, FIP-1. RRAGA is encoded by the human RRAGA gene, which is located on chromosome 9 at position p22.1.
RRAGA is a G-protein with GTP-binding activity that forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and plays a role in the cellular response to amino acid starvation and in the positive regulation of TORC1 signaling. RRAGA is active in the lysosome and nucleus through co-localization with the GATOR1 complex and is involved in the regulation of the mTORC1 signaling pathway.
RRAGA plays important roles in cell growth, metabolism, and disease, particularly in amino acid sensing and mTORC1 signaling. Abnormal expression or dysfunction of RRAGA has been associated with a variety of disorders, including neoplasms and metabolic diseases.
Recombinant Human Ras-related GTP-binding protein A (RRAGA), partial (CSB-RP034654h)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
RRAGA Antibody (CSB-PA03465A0Rb)
Validated Data
Immunohistochemistry of paraffin-embedded human lung tissue using CSB-PA03465A0Rb at dilution of 1:100
Immunofluorescence staining of A549 cells with CSB-PA03465A0Rb at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
The following RRAGA reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
RRAGA Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA03465A0Rb | RRAGA Antibody | Human | ELISA, IHC, IF |
CSB-PA03465C0Rb | RRAGA Antibody, FITC conjugated | Human | |
CSB-PA03465D0Rb | RRAGA Antibody, Biotin conjugated | Human | ELISA |
CSB-PA590465 | RRAGA/RRAGB Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA022239 | RRAGA Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA071515 | RRAGA Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
RRAGA Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP668782BO CSB-EP668782BO CSB-BP668782BO CSB-MP668782BO CSB-EP668782BO-B |
Recombinant Bovine Ras-related GTP-binding protein A (RRAGA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RRAGA Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP733938RA CSB-EP733938RA CSB-BP733938RA CSB-MP733938RA CSB-EP733938RA-B |
Recombinant Rat Ras-related GTP-binding protein A (Rraga) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
RRAGA Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP752099HU CSB-EP752099HU CSB-BP752099HU CSB-MP752099HU CSB-EP752099HU-B |
Recombinant Human Ras-related GTP-binding protein A (RRAGA) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-RP034654h | Recombinant Human Ras-related GTP-binding protein A (RRAGA), partial | E.coli |
RRAGA Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP767346MO CSB-EP767346MO CSB-BP767346MO CSB-MP767346MO CSB-EP767346MO-B |
Recombinant Mouse Ras-related GTP-binding protein A (Rraga) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |