Histone-lysine N-methyltransferase SETDB1 is a protein in humans that is encoded by SETDB1 gene. Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells.
The following SETDB1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SETDB1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021110GA01HU | SETDB1 Antibody |
Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA619960ESR1HU | SETDB1 Antibody |
Human, Rat | ELISA, WB, IHC |
SETDB1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP021110MO CSB-EP021110MO CSB-BP021110MO CSB-MP021110MO CSB-EP021110MO-B |
Recombinant Mouse Histone-lysine N-methyltransferase SETDB1 (Setdb1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SETDB1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP619960HU CSB-BP619960HU CSB-MP619960HU CSB-EP619960HU-B |
Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) |
Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP619960HU | Recombinant Human Histone-lysine N-methyltransferase SETDB1 (SETDB1) |
E.coli |
SETDB1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP764240XBE CSB-EP764240XBE CSB-BP764240XBE CSB-MP764240XBE CSB-EP764240XBE-B |
Recombinant Xenopus laevis Histone-lysine N-methyltransferase SETDB1 (setdb1), partial |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |