SGSH

SGSH (N-sulfoglucosamine sulfohydrolase) is a pivotal enzyme whose structure is composed of multiple amino acids, forming a unique active site that recognizes and catalyzes the degradation of heparan sulfate molecules. SGSH plays a central role in the lysosomal degradation of heparan sulfate, contributing to the maintenance of normal function and homeostasis of the extracellular matrix. While SGSH primarily participates in metabolic processes through enzymatic catalysis, it may also indirectly influence certain cellular signaling pathways, as heparan sulfate is an essential component of the extracellular matrix that interacts with various cell surface receptors and signaling molecules.