SH2B adapter protein 2 is a protein in humans that is encoded by SH2B2 gene. Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.
The following SH2B2 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SH2B2 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA006660 | SH2B2 Antibody |
Human,Mouse,Rat | WB, ELISA |
CSB-PA203041 | SH2B2 Antibody |
Human,Rat | ELISA,IHC |
CSB-PA038897 | SH2B2 Antibody |
Human,Rat | ELISA,IHC |
SH2B2 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP021207HU CSB-EP021207HU CSB-BP021207HU CSB-MP021207HU CSB-EP021207HU-B |
Recombinant Human SH2B adapter protein 2 (SH2B2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SH2B2 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP888308MO CSB-EP888308MO CSB-BP888308MO CSB-MP888308MO CSB-EP888308MO-B |
Recombinant Mouse SH2B adapter protein 2 (Sh2b2) |
Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |