SHC-transforming protein 1 is a protein in humans that is encoded by SHC1 gene. Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span.
The following SHC1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
SHC1 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA021253GA01HU | SHC1 Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA907557 | Phospho-SHC1 (Tyr349) Antibody | Human,Mouse | ELISA,WB,IF |
CSB-PA216875 | Phospho-SHC1 (Tyr427) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA065779 | SHC1 (Ab-427) Antibody | Human,Mouse,Rat | ELISA,WB,IHC,IF |
CSB-PA208610 | SHC1 (Ab-349) Antibody | Human,Mouse | ELISA,WB,IF |
CSB-PA000670 | Phospho-SHC1 (Y349) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA000671 | Phospho-SHC1 (Y427) Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA004082 | SHC1 Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA050054 | Phospho-SHC1 (S36) Antibody | Human,Mouse | IHC, ELISA |
CSB-PA050055 | SHC1 Antibody | Human,Mouse,Rat | WB, IHC, IP, ELISA |
CSB-PA021253LA01HU | SHC1 Antibody | Human | ELISA, IHC, IF |
CSB-PA021253LB01HU | SHC1 Antibody, HRP conjugated | Human | ELISA |
CSB-PA021253LC01HU | SHC1 Antibody, FITC conjugated | Human | |
CSB-PA021253LD01HU | SHC1 Antibody, Biotin conjugated | Human | ELISA |
SHC1 Antibodies for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA413838XA01STA | SHC1 Antibody | Saccharomyces cerevisiae (strain YJM789) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
SHC1 Antibodies for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA327920XA01SVG | SHC1 Antibody | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | ELISA, WB (ensure identification of antigen) |
SHC1 Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP021253MO CSB-EP021253MO CSB-BP021253MO CSB-MP021253MO CSB-EP021253MO-B |
Recombinant Mouse SHC-transforming protein 1 (Shc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP021253HU CSB-EP021253HU CSB-BP021253HU CSB-MP021253HU CSB-EP021253HU-B |
Recombinant Human SHC-transforming protein 1 (SHC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP327920SVG CSB-EP327920SVG CSB-BP327920SVG CSB-MP327920SVG CSB-EP327920SVG-B |
Recombinant Saccharomyces cerevisiae Protein SHC1 (SHC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Saccharomyces cerevisiae (strain YJM789) (Baker's yeast)
Code | Product Name | Source |
---|---|---|
CSB-YP413838STA CSB-EP413838STA CSB-BP413838STA CSB-MP413838STA CSB-EP413838STA-B |
Recombinant Saccharomyces cerevisiae Protein SHC1 (SHC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Bos taurus (Bovine)
Code | Product Name | Source |
---|---|---|
CSB-YP612560BO CSB-EP612560BO CSB-BP612560BO CSB-MP612560BO CSB-EP612560BO-B |
Recombinant Bovine SHC-transforming protein 1 (SHC1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP711720RA CSB-EP711720RA CSB-BP711720RA CSB-MP711720RA CSB-EP711720RA-B |
Recombinant Rat SHC-transforming protein 1 (Shc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP735718PYX CSB-EP735718PYX CSB-BP735718PYX CSB-MP735718PYX CSB-EP735718PYX-B |
Recombinant Pongo abelii SHC-transforming protein 1 (SHC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
SHC1 Proteins for Xenopus laevis (African clawed frog)
Code | Product Name | Source |
---|---|---|
CSB-YP806794XBE CSB-EP806794XBE CSB-BP806794XBE CSB-MP806794XBE CSB-EP806794XBE-B |
Recombinant Xenopus laevis SHC-transforming protein 1 (shc1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |