SLC25A10

The SLC25A10 gene encodes the mitochondrial dicarboxylate carrier protein, also commonly known as DIC. This protein is crucial for transporting dicarboxylates across the inner mitochondrial membrane. It plays a key role in several metabolic pathways, such as the tricarboxylic acid (TCA) cycle, by facilitating the exchange of dicarboxylates like malate and succinate.
Mutations in SLC25A10 can lead to various metabolic disorders, including mitochondrial dicarboxylate carrier deficiency, which may cause symptoms like hypoglycemia and metabolic acidosis. Regarding drug development, researchers are exploring potential therapeutic agents to target this protein for treating associated metabolic diseases, aiming to restore normal metabolic function.