SMOX

SMOX stands for Spermine Oxidase, also commonly known as PAOh1. This enzyme plays a crucial role in polyamine catabolism. It specifically oxidizes spermine to spermidine, leading to the production of hydrogen peroxide. SMOX is involved in the polyamine metabolic pathway, which is essential for cell growth, proliferation, and survival.
Dysregulation of SMOX has been associated with various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. Due to its significant role, SMOX has become a potential target for drug development. Researchers are actively exploring inhibitors of SMOX to develop new therapies for related diseases, but the progress is still in the pre - clinical and early - clinical stages.