STAMBP

STAMBP, also known as STAM-binding protein, is a key protein involved in cellular signaling. It is also commonly referred to as AMSH. STAMBP functions by deubiquitinating specific substrates, which is crucial for modulating endosomal sorting and signal transduction. It participates in the MAPK and JAK - STAT signaling pathways. Malfunction of STAMBP has been linked to certain autoimmune diseases and cancers.
Regarding drug development, researchers are exploring small - molecule inhibitors targeting STAMBP to regulate its deubiquitinating activity. These efforts aim to develop novel therapies for related diseases, with the expectation of bringing new treatment options for patients suffering from STAMBP - associated disorders.