SYNGR2

Synaptogyrin-2 (encoded by SYNGR2) is an integral membrane protein of synaptic vesicles, with aliases including SGYR2 and synaptogyrin II. It regulates synaptic vesicle trafficking and exocytosis by interacting with SNARE complex components (e.g., syntaxin-1), facilitating neurotransmitter release at presynaptic terminals.
Dysregulation of SYNGR2 is linked to neuropsychiatric disorders like schizophrenia (via genome-wide association studies) and autism spectrum disorders, likely due to impaired synaptic function. While no drugs directly targeting SYNGR2 are approved, it is a potential candidate in research on modulating synaptic vesicle dynamics for neurological condition treatments.