TEAD1

Transcriptional enhancer factor TEF-1 is a protein in humans that is encoded by TEAD1 gene. Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF).

TEAD1 Antibodies

TEAD1 Antibodies for Homo sapiens (Human)

TEAD1 Antibodies for Human

TEAD1 Proteins

TEAD1 Proteins for Mus musculus (Mouse)

TEAD1 Proteins for Homo sapiens (Human)

TEAD1 ELISA Kit

TEAD1 ELISA Kit for Homo sapiens (Human)

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