TOP2A

TOP2A, DNA topoisomerase IIα, alias DNA topoisomerase IIα, is an enzyme encoded by the TOP2A gene, which is widely present in eukaryotic cells, and is mainly involved in the regulation of DNA superhelix during DNA replication, repair, and transcription.The mechanism of action of TOP2A is to eliminate DNA superhelix and tangles by cleaving and rejoining a strand of DNA. TOP2A regulates the topology of DNA by cutting and rejoining a strand of DNA, eliminating DNA superhelix and tangles.TOP2A plays a role in the cell cycle, especially in the S-phase and G2-phase, and is essential for DNA synthesis and repair.

TOP2A has a wide range of biological significance, which not only participates in the normal metabolism process of DNA, but also is closely related to the development of many diseases.Abnormal expression or dysfunction of TOP2A is associated with the development of certain cancers. The abnormal expression or dysfunction of TOP2A has been associated with the development of certain cancers, such as prostate, breast and bladder cancers, etc. TOP2A is also the target of some anticancer drugs, such as anthracycline antibiotics and comedones, which inhibit the activity of TOP2A to prevent the proliferation of tumor cells. Therefore, TOP2A is a potential target in cancer therapy, and the development and study of drugs targeting TOP2A is of great significance for cancer treatment .