E3 ubiquitin-protein ligase TRIP12 is a protein in humans that is encoded by TRIP12 gene. E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A.
The following TRIP12 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
TRIP12 Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA617924ESR2HU | TRIP12 Antibody |
Human | ELISA, IHC |
TRIP12 Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA229075XA01DIL | trip12 Antibody |
Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
TRIP12 Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP617924HU CSB-MP617924HU CSB-EP617924HU-B |
Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial |
Yeast Mammalian cell In Vivo Biotinylation in E.coli |
CSB-EP617924HU | Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial |
E.coli |
CSB-BP617924HU | Recombinant Human E3 ubiquitin-protein ligase TRIP12 (TRIP12), partial |
Baculovirus |