TRPM8

TRPM8, the transient receptor potential M8 ion channel, is expressed in a wide variety of mammals, especially in sensory neurons.The mechanism of action of TRPM8 is to act as a cold receptor, which is activated when the temperature drops, allowing calcium and sodium ions to flow into the cell, thereby triggering cold sensory signalling.TRPM8 is important for animals to sense changes in environmental temperature and to adapt to cold environments. In addition, TRPM8 has been implicated in the development of certain diseases, such as prostate, bladder, and breast cancers.The 2021 Nobel Prize in Physiology or Medicine was awarded to the study of temperature-sensitive TRP channels, which further highlights the importance of channels such as TRPM8 in sensing heat and cold and adapting to environmental temperatures.