TRPS1

TRPS1, the transcriptional repressor GATA binding 1. alias GC79, LGCR etc. It is encoded by the human TRPS1 gene, which is located in the q23.3 region of chromosome 8.
The TRPS1 protein is a zinc-finger transcription factor that functions primarily in the nucleus and regulates the activity of other genes, especially those controlling bone and cartilage growth, by binding to specific regions of DNA. The mechanism of action of TRPS1 involves binding to the kinesin light-chain proteins and inhibiting their transcriptional activity.
TRPS1 plays an important role in regulating gene expression and controlling bone and cartilage growth, and its aberrant function has been associated with Hairy Nose and Toe Syndrome, a hereditary disorder that results in bone and joint deformities, abnormal facial features, and abnormalities of the skin, hair, teeth, sweat glands, and nails. Mutations or deletions of the TRPS1 gene can result in the development of TRPS types I and II, which affect the growth, development, and health of individuals.

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Recombinant Human Zinc finger transcription factor Trps1 (TRPS1), partial