TWIST1

TWIST1, the distortion spiral transcription factor 1, is a transcription factor encoded by the TWIST1 gene. It is part of the basic helix-loop-helix (bHLH) superfamily and is expressed across various tissues. TWIST1 binds to E-box elements in DNA sequences, regulating gene expression and influencing cell proliferation, differentiation, and migration. Its abnormal expression is often associated with diseases, particularly cancer, where high levels of TWIST1 are linked to tumor invasion, metastasis, and poor prognosis. TWIST1's role in promoting epithelial-mesenchymal transition (EMT) and enhancing tumor cell invasion and metastasis make it a potential target for cancer research and treatment.