UGDH

UDP-glucose 6-dehydrogenase (UGDH), also known as UGD or UDPGD, is a key enzyme in the glucuronate pathway. It catalyzes NAD+-dependent oxidation of UDP-glucose to UDP-glucuronic acid—a precursor for glycosaminoglycans (GAGs) like hyaluronan and chondroitin sulfate, critical components of the extracellular matrix (ECM).
UGDH activity is linked to ECM remodeling, regulated by pathways such as TGF-β. Dysregulation causes fibrotic disorders (liver/renal fibrosis) via excessive GAG accumulation; its overexpression in cancers drives metastasis. Small-molecule inhibitors targeting UGDH are under investigation as potential therapeutics for fibrosis and malignancies.

Validated Data

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

UGDH Antibody (CSB-PA132780)

Validated Data

Western blot analysis of extracts from COLO cells, using UGDH antibody.

The following UGDH reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

UGDH Antibodies

UGDH Proteins

UGDH Antibodies

UGDH Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA025567GA01HU	UGDH Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA025567HA01HU	UGDH Antibody	Human	ELISA
CSB-PA132780	UGDH Antibody	Human,Mouse,Rat	ELISA,WB
CSB-PA060041	UGDH Antibody	Human,Mouse,Rat	WB, IHC, ELISA

UGDH Proteins

UGDH Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP025567HU CSB-BP025567HU CSB-MP025567HU CSB-EP025567HU-B	Recombinant Human UDP-glucose 6-dehydrogenase (UGDH)	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-EP025567HU	Recombinant Human UDP-glucose 6-dehydrogenase (UGDH)	E.coli

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UGDH

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